ABSTRACT
@#AIM: To evaluate the efficacy of FS-LASIK combined with rapid corneal collagen cross-linking in treatment of high myopia.<p>METHODS: A prospective self-control study. Totally 42 patients(81 eyes)with high myopia treated by FS-LASIK combined with rapid corneal collagen cross-linking in our hospital from June to September 2017 were followed up for 6mo. The uncorrected visual acuity(UCVA), spherical equivalent(SE), corneal morphological parameters, corrected intraocular pressure and complications were observed.<p>RESULTS: At 6mo after operation, the UCVA(LogMAR)increased from 1.44±0.18 before operation to -0.03±0.04, the SE degree reduced from -8.01±1.23D to -0.06±0.54D, the steepest corneal curvature(Steep K)decreased from 44.23±0.80D to 37.39±1.17D at 6mo after operation, the flattest corneal curvature(Fleep K)decreased from 42.87±0.61D before operation to 36.84±0.99D after operation. And the thinnest point thickness of cornea decreased from 525.33±30.42μm to 402.12±28.04μm, the corrected intraocular pressure decreased from 17.77±2.16mmHg to 16.69±0.41mmHg. There were no significant changes in the posterior surface height of thinnest cornea and the endothelial cell density. No corneal infections, serious non-infectious inflammation and complications related to corneal flaps were found during follow-up.<p>CONCLUSION: FS-LASIK combined with rapid corneal collagen cross-linking is safe and effective in treatment of high myopia. The corneal morphology and refraction are relatively stable after surgery.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the high-risk factors for the quality of general movements (GMs), which has a predictive value for brain dysfunction in infants.</p><p><b>METHODS</b>A total of 618 infants in the stage of writhing movements and 539 infants in the stage of fidgety movements were selected separately for the evaluation of GMs. The high-risk factors for the quality of GMs in infants were analyzed by ANOVA, chi-square test, and multivariate logistic regression.</p><p><b>RESULTS</b>Multivariate logistic regression analysis showed that the factors significantly associated with the quality of GMs in the stage of writhing movements were gestational age (OR=0.762, P<0.001), birth weight (OR=0.264, P<0.001), severe asphyxia (OR=2.445, P=0.012), and intrauterine distress (OR=4.865, P<0.001); the factors significantly associated with the quality of GMs in the stage of fidget movements were gestational age (OR=0.786, P=0.003), birth weight (OR=0.217, P<0.001), severe asphyxia (OR=3.765, P=0.001), and hyperbilirubinemia (OR=2.640, P=0.028).</p><p><b>CONCLUSIONS</b>Low gestational age, low birth weight, severe asphyxia, hyperbilirubinemia and intrauterine distress are high-risk factors for abnormal GMs in infants, and early screening and intervention should be performed to reduce the incidence of abnormal nervous system sequelae.</p>